nterleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1219691/

Biochem J. 1998 Sep 1; 334(Pt 2): 297–314. 

PMCID: PMC1219691

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

TGF-β1/Smad signal pathway

https://en.m.wikipedia.org/wiki/TGF_beta_signaling_pathway
http://media.cellsignal.com/www/pdfs/science/pathways/TGF_beta.pdf



C. sinensis exerted antifibrotic effect through suppression of TGF-β1/Smad pathway.

Food and Chemical Toxicology

August 2013, Vol.58:487–494, doi:10.1016/j.fct.2013.04.037

Inhibition of TGF-β1/Smad signal pathway is involved in the effect of Cordyceps sinensis against renal fibrosis in 5/6 nephrectomy rats

The Effect of Gypenosides
on TGF-β1/Smad Pathway in Liver Fibrosis
Induced by Carbon Tetrachloride in Rats 

Int. j. integr. med., 2013, Vol. 1, 23:2013 

JAK/STAT signaling pathway

Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway.

Consist of three main components:
1. Receptor(some ligand such as EPO, growth hormone, interferones and interleukins)
2. JAK
3. STAT
(Video: https://youtu.be/vdEAX-J4xyk)

JAK activation stimulates cell proliferation, differentiation, cell migration and apoptosis. 

CELL SCIENCE AT A GLANCE

The JAK/STAT signaling pathway

Jason S. Rawlings, Kristin M. Rosler, Douglas A. Harrison

Journal of Cell Science  2004  117: 1281-1283;  doi: 10.1242/jcs.00963

http://jcs.biologists.org/content/joces/117/8/1281.full.pdf

https://zh.m.wikipedia.org/zh-tw/JAK-STAT信号通路

https://en.m.wikipedia.org/wiki/JAK-STAT_signaling_pathway